Detailed information of TA system TA027064

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1615004..1615523
• Accession: NC_017576
• Organism: Streptococcus gallolyticus subsp. gallolyticus ATCC 43143

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F5WVW3
• Locus tag: SGGB_RS08010
• Protein ID: WP_012962242.1
• Coordinates: 1615004..1615282 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F5WVW4
• Locus tag: SGGB_RS08015
• Protein ID: WP_012962243.1
• Coordinates: 1615275..1615523 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGGB_RS07980	1610321..1610929	-	609	WP_009854651.1	TVP38/TMEM64 family protein	-
SGGB_RS07990	1611177..1611479	-	303	WP_013643299.1	PepSY domain-containing protein	-
SGGB_RS07995	1611722..1613254	-	1533	WP_013643300.1	HAMP domain-containing histidine kinase	-
SGGB_RS08000	1613199..1613891	-	693	WP_012962240.1	response regulator transcription factor	-
SGGB_RS08005	1613997..1614875	-	879	WP_012962241.1	DUF3114 domain-containing protein	-
SGGB_RS08010	1615004..1615282	-	279	WP_012962242.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SGGB_RS08015	1615275..1615523	-	249	WP_012962243.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SGGB_RS08020	1615850..1616368	+	519	WP_009854658.1	TetR/AcrR family transcriptional regulator	-
SGGB_RS08025	1616482..1618251	+	1770	WP_009854659.1	oleate hydratase	-
SGGB_RS08030	1618384..1619208	-	825	WP_043910976.1	class C sortase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M)	-	1602105..1748385	146280

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 11043.84 Da
• Isoelectric Point: 9.3104

>T27064 WP_012962242.1 NC_017576:c1615282-1615004 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
MLKIKYHRQFKRDYKLALKRGLKASKLEEVLEILIKGESLPEKYRDHQLVASKYYQNVRECHIQPDWLLIYQIDDDNLIL
NLVRTGSHSDLF

Nucleotide

• Length: 279 bp

>T27064 NC_017576:c1615282-1615004 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
ATGCTTAAAATTAAATACCACAGACAGTTTAAAAGGGATTATAAACTAGCTTTAAAACGTGGTTTAAAAGCTTCCAAACT
AGAGGAAGTCTTAGAAATTTTAATAAAGGGTGAAAGTTTACCAGAAAAATATAGAGACCACCAACTAGTGGCAAGTAAAT
ATTATCAAAATGTTAGAGAATGTCATATTCAGCCTGATTGGTTATTAATTTATCAGATTGATGATGATAATTTGATTTTG
AATTTAGTGCGAACGGGTAGTCATTCGGATTTATTTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9204.69 Da
• Isoelectric Point: 4.3193

>AT27064 WP_012962243.1 NC_017576:c1615523-1615275 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
MTTITFKVDDEMKKEATELYKSMGLDLSSALRLFIKQSLVTRSIPFVIKADELTPVLDDVVKGVNMSEEFTDVKSLMESL
DA

Nucleotide

• Length: 249 bp

>AT27064 NC_017576:c1615523-1615275 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
ATGACTACAATTACATTTAAAGTTGATGATGAAATGAAAAAGGAAGCAACTGAACTTTATAAATCAATGGGGCTAGATTT
ATCTAGTGCATTACGCTTGTTTATAAAGCAATCTCTTGTTACTCGTAGTATTCCTTTTGTTATTAAAGCTGATGAATTAA
CTCCTGTTCTTGATGATGTCGTAAAGGGTGTTAACATGAGTGAAGAATTTACTGATGTTAAAAGTTTGATGGAGAGTTTA
GATGCTTAA

Structures

Toxin

• AlphaFold DB: F5WVW3

Antitoxin

• AlphaFold DB: F5WVW4