270636

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3543028..3543648 Replicon chromosome
Accession NZ_CP117340
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM111

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ02_RS17650 Protein ID WP_001280991.1
Coordinates 3543430..3543648 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ02_RS17645 Protein ID WP_000344807.1
Coordinates 3543028..3543402 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ02_RS17635 (3538167) 3538167..3539360 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ02_RS17640 (3539383) 3539383..3542532 + 3150 WP_052897443.1 efflux RND transporter permease AcrB -
PQQ02_RS17645 (3543028) 3543028..3543402 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ02_RS17650 (3543430) 3543430..3543648 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ02_RS17655 (3543827) 3543827..3544378 + 552 WP_001278787.1 maltose O-acetyltransferase -
PQQ02_RS17660 (3544496) 3544496..3544966 + 471 WP_000136183.1 YlaC family protein -
PQQ02_RS17665 (3545022) 3545022..3545162 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ02_RS17670 (3545168) 3545168..3545428 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ02_RS17675 (3545653) 3545653..3547203 + 1551 WP_000213140.1 EAL domain-containing protein -
PQQ02_RS17685 (3547434) 3547434..3547823 + 390 WP_000961287.1 MGMT family protein -
PQQ02_RS17690 (3547856) 3547856..3548425 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270636 WP_001280991.1 NZ_CP117340:3543430-3543648 [Salmonella enterica subsp. enterica serovar Dublin]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270636 WP_000344807.1 NZ_CP117340:3543028-3543402 [Salmonella enterica subsp. enterica serovar Dublin]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References