Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 824098..824758 Replicon chromosome
Accession NZ_CP117340
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM111

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQQ02_RS03975 Protein ID WP_000244756.1
Coordinates 824345..824758 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQQ02_RS03970 Protein ID WP_000351186.1
Coordinates 824098..824364 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ02_RS03950 (820029) 820029..821462 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PQQ02_RS03955 (821617) 821617..821931 + 315 WP_001182980.1 N(4)-acetylcytidine aminohydrolase -
PQQ02_RS03960 (822093) 822093..822752 + 660 WP_000250289.1 hemolysin III family protein -
PQQ02_RS03965 (822868) 822868..823848 - 981 WP_000874174.1 tRNA-modifying protein YgfZ -
PQQ02_RS03970 (824098) 824098..824364 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQQ02_RS03975 (824345) 824345..824758 + 414 WP_000244756.1 protein YgfX Toxin
PQQ02_RS03980 (824811) 824811..825332 - 522 WP_001055885.1 flavodoxin FldB -
PQQ02_RS03985 (825445) 825445..826341 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQQ02_RS03990 (826365) 826365..827078 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQQ02_RS03995 (827084) 827084..828817 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270629 WP_000244756.1 NZ_CP117340:824345-824758 [Salmonella enterica subsp. enterica serovar Dublin]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270629 WP_000351186.1 NZ_CP117340:824098-824364 [Salmonella enterica subsp. enterica serovar Dublin]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References