270621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4218321..4218837 Replicon chromosome
Accession NZ_CP117338
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM095

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag PQP94_RS20710 Protein ID WP_000220578.1
Coordinates 4218321..4218605 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQP94_RS20715 Protein ID WP_000212724.1
Coordinates 4218595..4218837 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP94_RS20695 (4213533) 4213533..4215185 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
PQP94_RS20700 (4215594) 4215594..4217732 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQP94_RS20705 (4217853) 4217853..4218317 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP94_RS20710 (4218321) 4218321..4218605 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP94_RS20715 (4218595) 4218595..4218837 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQP94_RS20720 (4218915) 4218915..4220828 - 1914 WP_001212137.1 BglG family transcription antiterminator -
PQP94_RS20725 (4220845) 4220845..4221585 - 741 WP_000779263.1 KDGP aldolase family protein -
PQP94_RS20730 (4221582) 4221582..4222700 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP94_RS20735 (4222684) 4222684..4223817 - 1134 WP_274895759.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T270621 WP_000220578.1 NZ_CP117338:c4218605-4218321 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270621 WP_000212724.1 NZ_CP117338:c4218837-4218595 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References