Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/YoeB-RelB
Location 1114102..1114618 Replicon
Accession NC_017576
Organism Streptococcus gallolyticus subsp. gallolyticus ATCC 43143

Toxin (Protein)


Gene name Txe Uniprot ID F5X0X3
Locus tag SGGB_RS05575 Protein ID WP_014620143.1
Coordinates 1114102..1114359 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID F5X0X4
Locus tag SGGB_RS05580 Protein ID WP_012961966.1
Coordinates 1114352..1114618 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SGGB_RS05545 1109481..1110179 + 699 WP_014620138.1 GntR family transcriptional regulator -
SGGB_RS05550 1110198..1110377 + 180 WP_014620139.1 hypothetical protein -
SGGB_RS05555 1110423..1111275 - 853 Protein_1040 MurR/RpiR family transcriptional regulator -
SGGB_RS05560 1111445..1112428 + 984 WP_014620140.1 Gfo/Idh/MocA family oxidoreductase -
SGGB_RS05565 1112433..1112957 + 525 WP_014620141.1 heme-binding protein -
SGGB_RS05570 1112978..1114036 + 1059 WP_014620142.1 Gfo/Idh/MocA family oxidoreductase -
SGGB_RS05575 1114102..1114359 - 258 WP_014620143.1 Txe/YoeB family addiction module toxin Toxin
SGGB_RS05580 1114352..1114618 - 267 WP_012961966.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SGGB_RS05585 1114782..1115114 + 333 WP_009854181.1 putative DNA-binding protein -
SGGB_RS05590 1115185..1116750 + 1566 WP_014620144.1 signal recognition particle protein -
SGGB_RS05595 1116816..1117832 - 1017 WP_014620145.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10277.64 Da        Isoelectric Point: 8.7825

>T27062 WP_014620143.1 NC_017576:c1114359-1114102 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
MIKAWSDDAWNDYMYWYNQGNKATIKKINRLIKEIDRTPFTGIGKPEPLKHDLSGKWSRRITDEHRLIYSVDETTIYFYS
CKDHY

Download         Length: 258 bp

>T27062 NC_017576:c1114359-1114102 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
ATGATTAAAGCATGGTCTGACGATGCGTGGAACGACTATATGTATTGGTATAATCAAGGAAATAAAGCGACAATTAAAAA
AATTAATCGCCTAATCAAGGAGATTGACCGCACTCCTTTTACTGGTATTGGTAAACCTGAACCACTTAAACACGATTTAT
CTGGCAAATGGTCACGACGTATAACCGATGAACATCGTTTAATTTACAGTGTTGATGAGACTACTATTTACTTTTATTCT
TGCAAAGACCATTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10365.60 Da        Isoelectric Point: 4.6290

>AT27062 WP_012961966.1 NC_017576:c1114618-1114352 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
MEAVAYSNFRQNLKHYMKQVNDDAEPLIVTSKNIDDTVVVLSKRDYDSMQETFRIMSNNYLMNKIKRGDEQFKAANFQTH
ELLEVDDD

Download         Length: 267 bp

>AT27062 NC_017576:c1114618-1114352 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
ATGGAAGCTGTTGCATATTCAAATTTTAGACAAAATTTAAAACATTATATGAAACAAGTTAATGATGACGCTGAACCACT
TATTGTAACTTCTAAAAATATTGATGATACTGTCGTAGTCCTTTCAAAACGTGACTATGATAGCATGCAAGAAACATTTC
GCATTATGTCTAATAACTACCTAATGAATAAAATTAAACGCGGCGATGAACAATTCAAAGCAGCTAATTTTCAGACACAT
GAATTGCTCGAGGTAGATGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S5WCL9

Antitoxin

Source ID Structure
AlphaFold DB A0A1S5WCN9

References