Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3477044..3477664 Replicon chromosome
Accession NZ_CP117338
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM095

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP94_RS17180 Protein ID WP_001280991.1
Coordinates 3477446..3477664 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP94_RS17175 Protein ID WP_000344807.1
Coordinates 3477044..3477418 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP94_RS17165 (3472183) 3472183..3473376 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP94_RS17170 (3473399) 3473399..3476548 + 3150 WP_274895698.1 efflux RND transporter permease AcrB -
PQP94_RS17175 (3477044) 3477044..3477418 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP94_RS17180 (3477446) 3477446..3477664 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP94_RS17185 (3477843) 3477843..3478394 + 552 WP_274895699.1 maltose O-acetyltransferase -
PQP94_RS17190 (3478511) 3478511..3478981 + 471 WP_000136181.1 YlaC family protein -
PQP94_RS17195 (3479037) 3479037..3479177 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP94_RS17200 (3479183) 3479183..3479443 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP94_RS17205 (3479668) 3479668..3481218 + 1551 WP_000213139.1 EAL domain-containing protein -
PQP94_RS17215 (3481449) 3481449..3481838 + 390 WP_000961285.1 MGMT family protein -
PQP94_RS17220 (3481871) 3481871..3482440 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270617 WP_001280991.1 NZ_CP117338:3477446-3477664 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270617 WP_000344807.1 NZ_CP117338:3477044-3477418 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References