27061

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 641924..642410 Replicon
Accession NC_017576
Organism Streptococcus gallolyticus subsp. gallolyticus ATCC 43143

Toxin (Protein)


Gene name relE Uniprot ID F5WZP9
Locus tag SGGB_RS03405 Protein ID WP_013642846.1
Coordinates 642141..642410 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F5WZP8
Locus tag SGGB_RS03400 Protein ID WP_013642845.1
Coordinates 641924..642151 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SGGB_RS03380 638062..638376 + 315 WP_003063779.1 metalloregulator ArsR/SmtB family transcription factor -
SGGB_RS03385 638379..640262 + 1884 WP_013642843.1 cadmium-translocating P-type ATPase -
SGGB_RS03390 640421..640741 + 321 WP_013642844.1 multidrug efflux SMR transporter -
SGGB_RS03395 640958..641650 + 693 WP_009853732.1 phosphoglycerate mutase -
SGGB_RS03400 641924..642151 + 228 WP_013642845.1 hypothetical protein Antitoxin
SGGB_RS03405 642141..642410 + 270 WP_013642846.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SGGB_RS03410 642789..643355 - 567 WP_013642847.1 DUF3267 domain-containing protein -
SGGB_RS03415 643604..644125 + 522 WP_013642848.1 transcription repressor NadR -
SGGB_RS03420 644322..644876 + 555 WP_013642849.1 hypothetical protein -
SGGB_RS03425 645031..647184 + 2154 WP_013642850.1 penicillin-binding protein PBP2B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10582.65 Da        Isoelectric Point: 10.5078

>T27061 WP_013642846.1 NC_017576:642141-642410 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
MTYRLVVSDKVKKQLKKMDKHVRLMLAKDMKKHLDGLENPRQIGRALIGQFKGLWRYRIGNYRVICDIMDDELVILAIEI
GHRKDIYKN

Download         Length: 270 bp

>T27061 NC_017576:642141-642410 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
ATGACTTATAGATTAGTTGTTAGTGACAAGGTCAAGAAACAACTAAAGAAAATGGATAAGCATGTAAGGCTTATGCTTGC
TAAAGACATGAAGAAACACCTTGATGGTTTAGAGAACCCTAGACAAATTGGAAGAGCACTAATAGGTCAATTCAAAGGCC
TATGGCGTTACCGAATAGGAAATTATAGAGTTATTTGTGATATTATGGACGATGAATTAGTTATTCTTGCTATTGAAATC
GGACATAGAAAAGATATTTATAAAAACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8732.81 Da        Isoelectric Point: 4.3239

>AT27061 WP_013642845.1 NC_017576:641924-642151 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
MSIVSLRLNEKEEELFRSYSIHTGKTLSELFKTALAEQIEDQLDYETGIKALKEFKKNPVTHSIDDIIEEFENDL

Download         Length: 228 bp

>AT27061 NC_017576:641924-642151 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
ATGTCAATCGTATCACTTAGACTAAATGAAAAAGAAGAAGAACTTTTTAGAAGTTATTCTATCCATACAGGAAAGACATT
ATCAGAGTTGTTTAAAACAGCTTTAGCTGAACAAATTGAAGACCAATTAGATTATGAAACAGGCATTAAAGCATTGAAAG
AATTCAAAAAGAATCCTGTTACTCACTCTATTGATGATATTATTGAGGAGTTTGAAAATGACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F5WZP9

Antitoxin

Source ID Structure
AlphaFold DB A0A1S5WAU8

References