Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 838310..838970 Replicon chromosome
Accession NZ_CP117338
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM095

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQP94_RS04045 Protein ID WP_000244756.1
Coordinates 838557..838970 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQP94_RS04040 Protein ID WP_000351186.1
Coordinates 838310..838576 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP94_RS04020 (834238) 834238..835671 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PQP94_RS04025 (835830) 835830..836141 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PQP94_RS04030 (836305) 836305..836964 + 660 WP_000250289.1 hemolysin III family protein -
PQP94_RS04035 (837080) 837080..838060 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
PQP94_RS04040 (838310) 838310..838576 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQP94_RS04045 (838557) 838557..838970 + 414 WP_000244756.1 protein YgfX Toxin
PQP94_RS04050 (839023) 839023..839544 - 522 WP_001055885.1 flavodoxin FldB -
PQP94_RS04055 (839657) 839657..840553 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQP94_RS04060 (840577) 840577..841290 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQP94_RS04065 (841296) 841296..843029 + 1734 WP_274895860.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270609 WP_000244756.1 NZ_CP117338:838557-838970 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270609 WP_000351186.1 NZ_CP117338:838310-838576 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References