Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206524..207284 Replicon chromosome
Accession NZ_CP117338
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM095

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag PQP94_RS00970 Protein ID WP_000533909.1
Coordinates 206799..207284 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PQP94_RS00965 Protein ID WP_000965886.1
Coordinates 206524..206811 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP94_RS00940 (201819) 201819..202121 + 303 WP_000605590.1 YsaB family lipoprotein -
PQP94_RS00945 (202260) 202260..203171 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
PQP94_RS00950 (203181) 203181..205250 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
PQP94_RS00955 (205432) 205432..205707 + 276 Protein_189 IS3 family transposase -
PQP94_RS00960 (205879) 205879..206346 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
PQP94_RS00965 (206524) 206524..206811 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PQP94_RS00970 (206799) 206799..207284 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
PQP94_RS00975 (207656) 207656..208195 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
PQP94_RS00980 (208369) 208369..208581 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PQP94_RS00985 (208870) 208870..209160 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PQP94_RS00990 (209599) 209599..210309 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PQP94_RS00995 (210359) 210359..211333 - 975 WP_274895810.1 glyoxylate/hydroxypyruvate reductase GhrB -
PQP94_RS01000 (211552) 211552..212214 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T270606 WP_000533909.1 NZ_CP117338:206799-207284 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT270606 WP_000965886.1 NZ_CP117338:206524-206811 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References