Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 823..1345 Replicon plasmid pRM052_1
Accession NZ_CP117337
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM052

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag PQP91_RS23735 Protein ID WP_000220560.1
Coordinates 1064..1345 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag PQP91_RS23730 Protein ID WP_000121743.1
Coordinates 823..1074 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP91_RS23730 (PQP91_23730) 823..1074 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
PQP91_RS23735 (PQP91_23735) 1064..1345 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP91_RS23740 (PQP91_23740) 1491..1814 + 324 WP_001181909.1 hypothetical protein -
PQP91_RS23745 (PQP91_23745) 1859..2104 + 246 WP_000356542.1 hypothetical protein -
PQP91_RS23750 (PQP91_23750) 2094..2309 + 216 WP_001180117.1 hypothetical protein -
PQP91_RS23755 (PQP91_23755) 2402..2731 + 330 WP_000866650.1 hypothetical protein -
PQP91_RS23760 (PQP91_23760) 2774..2953 + 180 WP_001575529.1 hypothetical protein -
PQP91_RS23765 (PQP91_23765) 2975..3172 + 198 WP_001675595.1 hypothetical protein -
PQP91_RS23770 (PQP91_23770) 3185..3457 + 273 WP_000160399.1 hypothetical protein -
PQP91_RS23775 (PQP91_23775) 3783..4328 + 546 WP_000757691.1 DNA distortion polypeptide 1 -
PQP91_RS23780 (PQP91_23780) 4331..5512 + 1182 WP_000539536.1 MobP1 family relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 faeH / faeI / spvC / spvB 1..150540 150540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T270602 WP_000220560.1 NZ_CP117337:1064-1345 [Salmonella enterica subsp. enterica serovar Dublin]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT270602 WP_000121743.1 NZ_CP117337:823-1074 [Salmonella enterica subsp. enterica serovar Dublin]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References