27060

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 295504..296055 Replicon
Accession NC_017576
Organism Streptococcus gallolyticus subsp. gallolyticus ATCC 43143

Toxin (Protein)


Gene name relE Uniprot ID F5WYT2
Locus tag SGGB_RS01675 Protein ID WP_014619942.1
Coordinates 295504..295782 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1ZGU4
Locus tag SGGB_RS01680 Protein ID WP_014619943.1
Coordinates 295783..296055 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SGGB_RS01640 290570..290956 - 387 WP_043910750.1 hypothetical protein -
SGGB_RS01645 290934..292166 - 1233 WP_014619938.1 replication initiation factor domain-containing protein -
SGGB_RS01650 292379..294046 - 1668 WP_014619939.1 cell division protein FtsK -
SGGB_RS01655 294053..294463 - 411 WP_014619940.1 DUF961 family protein -
SGGB_RS01660 294486..294800 - 315 WP_000406626.1 hypothetical protein -
SGGB_RS01670 295139..295375 - 237 WP_014619941.1 hypothetical protein -
SGGB_RS01675 295504..295782 - 279 WP_014619942.1 type II toxin-antitoxin system YafQ family toxin Toxin
SGGB_RS01680 295783..296055 - 273 WP_014619943.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
SGGB_RS01685 296283..296750 + 468 WP_014619944.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
SGGB_RS01690 297385..297747 + 363 WP_008809667.1 helix-turn-helix transcriptional regulator -
SGGB_RS01695 297754..298605 + 852 WP_014619945.1 ImmA/IrrE family metallo-endopeptidase -
SGGB_RS01705 299242..299928 + 687 Protein_300 NTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 273149..300656 27507


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10893.81 Da        Isoelectric Point: 9.3997

>T27060 WP_014619942.1 NC_017576:c295782-295504 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
MYQVKFTSAFKKSYKRIKKRGLEMALLDEVIEKLRLGQTLEEKYRDHKLKGNFVGFRECHIKPDWLLIYLIEDDILTLTL
ADTGSHADLFKM

Download         Length: 279 bp

>T27060 NC_017576:c295782-295504 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
ATGTACCAAGTCAAGTTCACCTCTGCTTTTAAAAAGAGCTATAAACGGATTAAAAAGCGAGGTTTAGAGATGGCACTCTT
AGATGAAGTGATTGAAAAACTCCGTCTAGGTCAGACACTAGAAGAAAAATACCGTGACCATAAACTCAAAGGAAACTTTG
TTGGCTTTAGGGAATGTCACATCAAGCCAGATTGGCTCTTGATTTATCTGATTGAAGACGATATTTTGACTTTAACCTTA
GCCGACACGGGCAGTCATGCGGATTTGTTTAAGATGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9905.35 Da        Isoelectric Point: 4.7085

>AT27060 WP_014619943.1 NC_017576:c296055-295783 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
MATVPTQIRIDETVKAQATSLFNDLGMDMSSAVNIFLRQCLLRGGLPFTVELPNYSQKTLEALAEAKRISRDETVASYDN
LADLKKALDA

Download         Length: 273 bp

>AT27060 NC_017576:c296055-295783 [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
ATGGCAACTGTACCAACTCAAATTCGGATTGATGAAACTGTAAAAGCCCAAGCAACTTCATTATTTAATGACTTGGGGAT
GGATATGTCTAGTGCAGTCAATATTTTTCTTCGTCAATGTCTATTGCGTGGTGGGCTTCCTTTCACGGTTGAACTTCCCA
ATTATAGTCAAAAGACCTTAGAAGCTCTGGCAGAAGCTAAGCGTATTTCTCGTGATGAAACGGTTGCTTCTTATGACAAT
CTAGCAGATTTAAAGAAGGCTCTGGACGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F5WYT2

Antitoxin

Source ID Structure
AlphaFold DB A0A3R9JSK3

References