Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4343629..4344410 Replicon chromosome
Accession NZ_CP117336
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM052

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQP91_RS21450 Protein ID WP_000625912.1
Coordinates 4343629..4344120 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQP91_RS21455 Protein ID WP_001110450.1
Coordinates 4344117..4344410 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP91_RS21415 (4339089) 4339089..4339436 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
PQP91_RS21420 (4339412) 4339412..4341115 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
PQP91_RS21425 (4341152) 4341152..4341727 + 576 WP_001188509.1 transcriptional regulator -
PQP91_RS21435 (4341998) 4341998..4342072 - 75 Protein_4194 helix-turn-helix domain-containing protein -
PQP91_RS21440 (4342452) 4342452..4342529 + 78 Protein_4195 porin family protein -
PQP91_RS21445 (4342629) 4342629..4343381 + 753 WP_000842432.1 non-specific acid phosphatase -
PQP91_RS21450 (4343629) 4343629..4344120 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQP91_RS21455 (4344117) 4344117..4344410 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQP91_RS21460 (4344727) 4344727..4344949 + 223 Protein_4199 hypothetical protein -
PQP91_RS21465 (4345213) 4345213..4346088 + 876 WP_000921679.1 AraC family transcriptional regulator -
PQP91_RS21470 (4346085) 4346085..4346372 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP91_RS21475 (4346395) 4346395..4346610 + 216 WP_001595136.1 hypothetical protein -
PQP91_RS21480 (4346618) 4346618..4346887 + 270 WP_077906657.1 hypothetical protein -
PQP91_RS21485 (4347181) 4347181..4348086 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270599 WP_000625912.1 NZ_CP117336:c4344120-4343629 [Salmonella enterica subsp. enterica serovar Dublin]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270599 WP_001110450.1 NZ_CP117336:c4344410-4344117 [Salmonella enterica subsp. enterica serovar Dublin]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References