Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 4343629..4344410 | Replicon | chromosome |
Accession | NZ_CP117336 | ||
Organism | Salmonella enterica subsp. enterica serovar Dublin strain RM052 |
Toxin (Protein)
Gene name | TacT2 | Uniprot ID | A0A0R9NZI3 |
Locus tag | PQP91_RS21450 | Protein ID | WP_000625912.1 |
Coordinates | 4343629..4344120 (-) | Length | 164 a.a. |
Antitoxin (Protein)
Gene name | TacA2 | Uniprot ID | M7RNV8 |
Locus tag | PQP91_RS21455 | Protein ID | WP_001110450.1 |
Coordinates | 4344117..4344410 (-) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PQP91_RS21415 (4339089) | 4339089..4339436 | + | 348 | WP_000887832.1 | divalent cation tolerance protein CutA | - |
PQP91_RS21420 (4339412) | 4339412..4341115 | + | 1704 | WP_000068885.1 | protein-disulfide reductase DsbD | - |
PQP91_RS21425 (4341152) | 4341152..4341727 | + | 576 | WP_001188509.1 | transcriptional regulator | - |
PQP91_RS21435 (4341998) | 4341998..4342072 | - | 75 | Protein_4194 | helix-turn-helix domain-containing protein | - |
PQP91_RS21440 (4342452) | 4342452..4342529 | + | 78 | Protein_4195 | porin family protein | - |
PQP91_RS21445 (4342629) | 4342629..4343381 | + | 753 | WP_000842432.1 | non-specific acid phosphatase | - |
PQP91_RS21450 (4343629) | 4343629..4344120 | - | 492 | WP_000625912.1 | GNAT family N-acetyltransferase | Toxin |
PQP91_RS21455 (4344117) | 4344117..4344410 | - | 294 | WP_001110450.1 | DUF1778 domain-containing protein | Antitoxin |
PQP91_RS21460 (4344727) | 4344727..4344949 | + | 223 | Protein_4199 | hypothetical protein | - |
PQP91_RS21465 (4345213) | 4345213..4346088 | + | 876 | WP_000921679.1 | AraC family transcriptional regulator | - |
PQP91_RS21470 (4346085) | 4346085..4346372 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
PQP91_RS21475 (4346395) | 4346395..4346610 | + | 216 | WP_001595136.1 | hypothetical protein | - |
PQP91_RS21480 (4346618) | 4346618..4346887 | + | 270 | WP_077906657.1 | hypothetical protein | - |
PQP91_RS21485 (4347181) | 4347181..4348086 | - | 906 | WP_001268195.1 | YjiK family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17606.43 Da Isoelectric Point: 7.7297
>T270599 WP_000625912.1 NZ_CP117336:c4344120-4343629 [Salmonella enterica subsp. enterica serovar Dublin]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10949.56 Da Isoelectric Point: 8.6141
>AT270599 WP_001110450.1 NZ_CP117336:c4344410-4344117 [Salmonella enterica subsp. enterica serovar Dublin]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0R9NZI3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0R9PGG6 |