Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3545282..3545902 Replicon chromosome
Accession NZ_CP117336
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM052

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP91_RS17670 Protein ID WP_001280991.1
Coordinates 3545684..3545902 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP91_RS17665 Protein ID WP_000344807.1
Coordinates 3545282..3545656 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP91_RS17655 (3540421) 3540421..3541614 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP91_RS17660 (3541637) 3541637..3544786 + 3150 WP_052897443.1 efflux RND transporter permease AcrB -
PQP91_RS17665 (3545282) 3545282..3545656 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP91_RS17670 (3545684) 3545684..3545902 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP91_RS17675 (3546081) 3546081..3546632 + 552 WP_001278787.1 maltose O-acetyltransferase -
PQP91_RS17680 (3546750) 3546750..3547220 + 471 WP_000136183.1 YlaC family protein -
PQP91_RS17685 (3547276) 3547276..3547416 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP91_RS17690 (3547422) 3547422..3547682 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP91_RS17695 (3547907) 3547907..3549457 + 1551 WP_000213140.1 EAL domain-containing protein -
PQP91_RS17705 (3549688) 3549688..3550077 + 390 WP_000961287.1 MGMT family protein -
PQP91_RS17710 (3550110) 3550110..3550679 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270593 WP_001280991.1 NZ_CP117336:3545684-3545902 [Salmonella enterica subsp. enterica serovar Dublin]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270593 WP_000344807.1 NZ_CP117336:3545282-3545656 [Salmonella enterica subsp. enterica serovar Dublin]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References