Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4180900..4181681 Replicon chromosome
Accession NZ_CP117332
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM055

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A752VN12
Locus tag PQP79_RS20350 Protein ID WP_000622305.1
Coordinates 4180900..4181391 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag PQP79_RS20355 Protein ID WP_001110453.1
Coordinates 4181388..4181681 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP79_RS20325 (4176035) 4176035..4178473 - 2439 WP_023137200.1 F4 (K88) fimbrial usher FaeD -
PQP79_RS20330 (4178483) 4178483..4179022 - 540 WP_000721295.1 type 1 fimbrial protein -
PQP79_RS20335 (4179057) 4179057..4179347 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQP79_RS20340 (4179934) 4179934..4180161 + 228 WP_001112992.1 hypothetical protein -
PQP79_RS20345 (4180437) 4180437..4180685 - 249 Protein_3975 IS481 family transposase -
PQP79_RS20350 (4180900) 4180900..4181391 - 492 WP_000622305.1 GNAT family N-acetyltransferase Toxin
PQP79_RS20355 (4181388) 4181388..4181681 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
PQP79_RS20360 (4181999) 4181999..4182221 + 223 Protein_3978 hypothetical protein -
PQP79_RS20365 (4182485) 4182485..4183360 + 876 WP_023137202.1 AraC family transcriptional regulator -
PQP79_RS20370 (4183357) 4183357..4183644 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP79_RS20375 (4183637) 4183637..4183819 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
PQP79_RS20380 (4183839) 4183839..4183938 + 100 Protein_3982 hypothetical protein -
PQP79_RS20385 (4184048) 4184048..4184182 + 135 Protein_3983 hypothetical protein -
PQP79_RS20390 (4184477) 4184477..4185382 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4169455..4183819 14364


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270574 WP_000622305.1 NZ_CP117332:c4181391-4180900 [Salmonella enterica subsp. enterica serovar Muenster]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT270574 WP_001110453.1 NZ_CP117332:c4181681-4181388 [Salmonella enterica subsp. enterica serovar Muenster]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A752VN12

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References