270571

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3362347..3362967 Replicon chromosome
Accession NZ_CP117332
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM055

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP79_RS16450 Protein ID WP_001280991.1
Coordinates 3362749..3362967 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP79_RS16445 Protein ID WP_000344807.1
Coordinates 3362347..3362721 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP79_RS16435 (3357486) 3357486..3358679 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP79_RS16440 (3358702) 3358702..3361851 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP79_RS16445 (3362347) 3362347..3362721 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP79_RS16450 (3362749) 3362749..3362967 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP79_RS16455 (3363146) 3363146..3363697 + 552 WP_274881085.1 maltose O-acetyltransferase -
PQP79_RS16460 (3363815) 3363815..3364285 + 471 WP_000136183.1 YlaC family protein -
PQP79_RS16465 (3364341) 3364341..3364481 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP79_RS16470 (3364487) 3364487..3364747 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP79_RS16475 (3364972) 3364972..3366522 + 1551 WP_023136501.1 EAL domain-containing protein -
PQP79_RS16485 (3366753) 3366753..3367142 + 390 WP_000961285.1 MGMT family protein -
PQP79_RS16490 (3367175) 3367175..3367744 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270571 WP_001280991.1 NZ_CP117332:3362749-3362967 [Salmonella enterica subsp. enterica serovar Muenster]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270571 WP_000344807.1 NZ_CP117332:3362347-3362721 [Salmonella enterica subsp. enterica serovar Muenster]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References