270570

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2365909..2366431 Replicon chromosome
Accession NZ_CP117332
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM055

Toxin (Protein)


Gene name stbE Uniprot ID A0A5J1ICX1
Locus tag PQP79_RS11470 Protein ID WP_000221344.1
Coordinates 2366147..2366431 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP79_RS11465 Protein ID WP_000885424.1
Coordinates 2365909..2366157 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP79_RS11435 (2361925) 2361925..2362032 + 108 Protein_2234 hypothetical protein -
PQP79_RS11440 (2362278) 2362278..2363258 - 981 WP_000876799.1 nitronate monooxygenase -
PQP79_RS11445 (2363432) 2363432..2364340 - 909 WP_274879769.1 LysR family transcriptional regulator -
PQP79_RS11450 (2364742) 2364742..2364945 + 204 WP_001276024.1 DUF29 family protein -
PQP79_RS11455 (2365220) 2365220..2365552 - 333 WP_000253078.1 DUF1493 family protein -
PQP79_RS11460 (2365638) 2365638..2365757 - 120 Protein_2239 type II and III secretion system -
PQP79_RS11465 (2365909) 2365909..2366157 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP79_RS11470 (2366147) 2366147..2366431 + 285 WP_000221344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP79_RS11475 (2366550) 2366550..2366831 + 282 Protein_2242 RidA family protein -
PQP79_RS11480 (2366883) 2366883..2367962 - 1080 WP_274880955.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP79_RS11485 (2368155) 2368155..2368643 - 489 WP_023137021.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP79_RS11490 (2368688) 2368688..2370196 + 1509 WP_023223293.1 FAD-dependent oxidoreductase -
PQP79_RS11495 (2370186) 2370186..2371427 + 1242 WP_001095734.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11015.73 Da        Isoelectric Point: 10.5388

>T270570 WP_000221344.1 NZ_CP117332:2366147-2366431 [Salmonella enterica subsp. enterica serovar Muenster]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270570 WP_000885424.1 NZ_CP117332:2365909-2366157 [Salmonella enterica subsp. enterica serovar Muenster]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J1ICX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References