Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1870950..1871540 Replicon chromosome
Accession NZ_CP117332
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM055

Toxin (Protein)


Gene name pemK Uniprot ID A0A5V3ZYQ4
Locus tag PQP79_RS08875 Protein ID WP_023137319.1
Coordinates 1870950..1871282 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A613PBF1
Locus tag PQP79_RS08880 Protein ID WP_023137318.1
Coordinates 1871283..1871540 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP79_RS08865 (1867325) 1867325..1868587 + 1263 WP_023137322.1 integrase arm-type DNA-binding domain-containing protein -
PQP79_RS08870 (1869215) 1869215..1870099 - 885 WP_023137321.1 integrase domain-containing protein -
PQP79_RS08875 (1870950) 1870950..1871282 - 333 WP_023137319.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PQP79_RS08880 (1871283) 1871283..1871540 - 258 WP_023137318.1 hypothetical protein Antitoxin
PQP79_RS08885 (1871888) 1871888..1872094 - 207 WP_023137317.1 helix-turn-helix transcriptional regulator -
PQP79_RS08890 (1872091) 1872091..1872570 - 480 WP_023137316.1 hypothetical protein -
PQP79_RS08895 (1873208) 1873208..1875250 - 2043 WP_274880513.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11809.59 Da        Isoelectric Point: 9.3417

>T270565 WP_023137319.1 NZ_CP117332:c1871282-1870950 [Salmonella enterica subsp. enterica serovar Muenster]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSQASFNKLTRLPVVVPVTSGGNFARAAGFTVSLDDAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9398.87 Da        Isoelectric Point: 4.4488

>AT270565 WP_023137318.1 NZ_CP117332:c1871540-1871283 [Salmonella enterica subsp. enterica serovar Muenster]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQRRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKELL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5V3ZYQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A613PBF1

References