Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 212625..213385 Replicon chromosome
Accession NZ_CP117332
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM055

Toxin (Protein)


Gene name tacT Uniprot ID A0A3V9PR68
Locus tag PQP79_RS00990 Protein ID WP_000533907.1
Coordinates 212900..213385 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PQP79_RS00985 Protein ID WP_000965886.1
Coordinates 212625..212912 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP79_RS00965 (208030) 208030..208941 + 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
PQP79_RS00970 (208951) 208951..211020 + 2070 WP_001291742.1 glycine--tRNA ligase subunit beta -
PQP79_RS00975 (211410) 211410..211838 + 429 Protein_193 IS3 family transposase -
PQP79_RS00980 (211980) 211980..212447 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
PQP79_RS00985 (212625) 212625..212912 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PQP79_RS00990 (212900) 212900..213385 + 486 WP_000533907.1 GNAT family N-acetyltransferase Toxin
PQP79_RS00995 (213756) 213756..214295 - 540 WP_274881277.1 copper-binding periplasmic metallochaperone CueP -
PQP79_RS01000 (214467) 214467..214679 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PQP79_RS01005 (214967) 214967..215257 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PQP79_RS01010 (215696) 215696..216406 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PQP79_RS01015 (216456) 216456..217430 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
PQP79_RS01020 (217649) 217649..218311 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17715.46 Da        Isoelectric Point: 9.8719

>T270562 WP_000533907.1 NZ_CP117332:212900-213385 [Salmonella enterica subsp. enterica serovar Muenster]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALIEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT270562 WP_000965886.1 NZ_CP117332:212625-212912 [Salmonella enterica subsp. enterica serovar Muenster]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PR68

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References