Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 47266..47792 Replicon plasmid pRM074_1
Accession NZ_CP117330
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM074

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag PQP80_RS23440 Protein ID WP_000323025.1
Coordinates 47505..47792 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q5J3S4
Locus tag PQP80_RS23435 Protein ID WP_000534857.1
Coordinates 47266..47505 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP80_RS23400 (PQP80_23400) 43502..43726 - 225 WP_000743213.1 hypothetical protein -
PQP80_RS23405 (PQP80_23405) 43723..44460 - 738 WP_001446887.1 recombinase family protein -
PQP80_RS23410 (PQP80_23410) 44946..45086 - 141 WP_001044210.1 hypothetical protein -
PQP80_RS23415 (PQP80_23415) 45092..45796 - 705 WP_274880641.1 IS6-like element IS26 family transposase -
PQP80_RS23420 (PQP80_23420) 45808..46731 - 924 WP_274880643.1 HsdR -
PQP80_RS23425 (PQP80_23425) 46775..46924 - 150 WP_000550473.1 hypothetical protein -
PQP80_RS23430 (PQP80_23430) 47131..47241 - 111 Protein_51 protein YdfV -
PQP80_RS23435 (PQP80_23435) 47266..47505 + 240 WP_000534857.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
PQP80_RS23440 (PQP80_23440) 47505..47792 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
PQP80_RS23445 (PQP80_23445) 48096..48878 - 783 WP_001531258.1 IS21-like element ISSen3 family helper ATPase IstB -
PQP80_RS23450 (PQP80_23450) 48875..49897 - 1023 WP_000627495.1 IS21-like element ISSen3 family transposase -
PQP80_RS23455 (PQP80_23455) 50036..50260 + 225 Protein_56 hypothetical protein -
PQP80_RS23460 (PQP80_23460) 50697..50819 + 123 WP_274880647.1 hypothetical protein -
PQP80_RS23465 (PQP80_23465) 50853..51210 + 358 Protein_58 IS1 family transposase -
PQP80_RS23470 (PQP80_23470) 51897..51980 + 84 Protein_59 SOS response-associated peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid dfrA12 / aadA2 / qacE / sul1 / sul2 / aph(3'')-Ib / aph(6)-Id / floR - 1..64283 64283
- inside IScluster/Tn dfrA12 / aadA2 / qacE / sul1 / sul2 / aph(3'')-Ib / aph(6)-Id / floR - 20236..64089 43853


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T270561 WP_000323025.1 NZ_CP117330:47505-47792 [Salmonella enterica subsp. enterica serovar Muenster]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9085.55 Da        Isoelectric Point: 4.6820

>AT270561 WP_000534857.1 NZ_CP117330:47266-47505 [Salmonella enterica subsp. enterica serovar Muenster]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRKPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0NE60

References