Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4231132..4231913 Replicon chromosome
Accession NZ_CP117329
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM074

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A752VN12
Locus tag PQP80_RS20755 Protein ID WP_000622305.1
Coordinates 4231132..4231623 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag PQP80_RS20760 Protein ID WP_001110453.1
Coordinates 4231620..4231913 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP80_RS20730 (4226267) 4226267..4228705 - 2439 WP_023137200.1 F4 (K88) fimbrial usher FaeD -
PQP80_RS20735 (4228715) 4228715..4229254 - 540 WP_000721295.1 type 1 fimbrial protein -
PQP80_RS20740 (4229289) 4229289..4229579 - 291 WP_274880131.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQP80_RS20745 (4230166) 4230166..4230393 + 228 WP_001112992.1 hypothetical protein -
PQP80_RS20750 (4230669) 4230669..4230917 - 249 Protein_4055 IS481 family transposase -
PQP80_RS20755 (4231132) 4231132..4231623 - 492 WP_000622305.1 GNAT family N-acetyltransferase Toxin
PQP80_RS20760 (4231620) 4231620..4231913 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
PQP80_RS20765 (4232231) 4232231..4232453 + 223 Protein_4058 hypothetical protein -
PQP80_RS20770 (4232717) 4232717..4233592 + 876 WP_023137202.1 AraC family transcriptional regulator -
PQP80_RS20775 (4233589) 4233589..4233876 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP80_RS20780 (4233869) 4233869..4234051 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
PQP80_RS20785 (4234071) 4234071..4234170 + 100 Protein_4062 hypothetical protein -
PQP80_RS20790 (4234280) 4234280..4234414 + 135 Protein_4063 hypothetical protein -
PQP80_RS20795 (4234709) 4234709..4235614 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4219687..4234051 14364


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270557 WP_000622305.1 NZ_CP117329:c4231623-4231132 [Salmonella enterica subsp. enterica serovar Muenster]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT270557 WP_001110453.1 NZ_CP117329:c4231913-4231620 [Salmonella enterica subsp. enterica serovar Muenster]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A752VN12

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References