Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4093535..4094051 Replicon chromosome
Accession NZ_CP117329
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM074

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag PQP80_RS20040 Protein ID WP_000220578.1
Coordinates 4093535..4093819 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQP80_RS20045 Protein ID WP_000212724.1
Coordinates 4093809..4094051 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP80_RS20025 (4088650) 4088650..4090302 + 1653 WP_023137279.1 alpha,alpha-phosphotrehalase -
PQP80_RS20030 (4090712) 4090712..4092850 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
PQP80_RS20035 (4093067) 4093067..4093531 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP80_RS20040 (4093535) 4093535..4093819 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP80_RS20045 (4093809) 4093809..4094051 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQP80_RS20050 (4094129) 4094129..4096042 - 1914 WP_274880116.1 BglG family transcription antiterminator -
PQP80_RS20055 (4096059) 4096059..4096799 - 741 WP_000779262.1 KDGP aldolase family protein -
PQP80_RS20060 (4096796) 4096796..4097914 - 1119 WP_023137277.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP80_RS20065 (4097898) 4097898..4099031 - 1134 Protein_3922 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T270556 WP_000220578.1 NZ_CP117329:c4093819-4093535 [Salmonella enterica subsp. enterica serovar Muenster]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270556 WP_000212724.1 NZ_CP117329:c4094051-4093809 [Salmonella enterica subsp. enterica serovar Muenster]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References