Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3412594..3413214 Replicon chromosome
Accession NZ_CP117329
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM074

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP80_RS16855 Protein ID WP_001280991.1
Coordinates 3412996..3413214 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP80_RS16850 Protein ID WP_000344807.1
Coordinates 3412594..3412968 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP80_RS16840 (3407733) 3407733..3408926 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP80_RS16845 (3408949) 3408949..3412098 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP80_RS16850 (3412594) 3412594..3412968 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP80_RS16855 (3412996) 3412996..3413214 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP80_RS16860 (3413393) 3413393..3413944 + 552 WP_274880007.1 maltose O-acetyltransferase -
PQP80_RS16865 (3414062) 3414062..3414532 + 471 WP_000136183.1 YlaC family protein -
PQP80_RS16870 (3414588) 3414588..3414728 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP80_RS16875 (3414734) 3414734..3414994 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP80_RS16880 (3415219) 3415219..3416769 + 1551 WP_023136501.1 EAL domain-containing protein -
PQP80_RS16890 (3417000) 3417000..3417389 + 390 WP_000961285.1 MGMT family protein -
PQP80_RS16895 (3417422) 3417422..3417991 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270554 WP_001280991.1 NZ_CP117329:3412996-3413214 [Salmonella enterica subsp. enterica serovar Muenster]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270554 WP_000344807.1 NZ_CP117329:3412594-3412968 [Salmonella enterica subsp. enterica serovar Muenster]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References