270553

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2415972..2416494 Replicon chromosome
Accession NZ_CP117329
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM074

Toxin (Protein)


Gene name stbE Uniprot ID A0A5J1ICX1
Locus tag PQP80_RS11870 Protein ID WP_000221344.1
Coordinates 2416210..2416494 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP80_RS11865 Protein ID WP_000885424.1
Coordinates 2415972..2416220 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP80_RS11835 (2411988) 2411988..2412095 + 108 Protein_2314 hypothetical protein -
PQP80_RS11840 (2412341) 2412341..2413321 - 981 WP_000876799.1 nitronate monooxygenase -
PQP80_RS11845 (2413495) 2413495..2414403 - 909 WP_274879769.1 LysR family transcriptional regulator -
PQP80_RS11850 (2414805) 2414805..2415008 + 204 WP_001276024.1 DUF29 family protein -
PQP80_RS11855 (2415283) 2415283..2415615 - 333 WP_000253078.1 DUF1493 family protein -
PQP80_RS11860 (2415701) 2415701..2415820 - 120 Protein_2319 type II and III secretion system -
PQP80_RS11865 (2415972) 2415972..2416220 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP80_RS11870 (2416210) 2416210..2416494 + 285 WP_000221344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP80_RS11875 (2416613) 2416613..2416894 + 282 Protein_2322 RidA family protein -
PQP80_RS11880 (2416946) 2416946..2418025 - 1080 WP_274879770.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP80_RS11885 (2418218) 2418218..2418706 - 489 WP_023137021.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP80_RS11890 (2418751) 2418751..2420259 + 1509 WP_023223293.1 FAD-dependent oxidoreductase -
PQP80_RS11895 (2420249) 2420249..2421490 + 1242 WP_001095734.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11015.73 Da        Isoelectric Point: 10.5388

>T270553 WP_000221344.1 NZ_CP117329:2416210-2416494 [Salmonella enterica subsp. enterica serovar Muenster]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270553 WP_000885424.1 NZ_CP117329:2415972-2416220 [Salmonella enterica subsp. enterica serovar Muenster]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J1ICX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References