Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1921511..1922101 Replicon chromosome
Accession NZ_CP117329
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM074

Toxin (Protein)


Gene name pemK Uniprot ID A0A5V3ZYQ4
Locus tag PQP80_RS09275 Protein ID WP_023137319.1
Coordinates 1921511..1921843 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A613PBF1
Locus tag PQP80_RS09280 Protein ID WP_023137318.1
Coordinates 1921844..1922101 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP80_RS09265 (1917886) 1917886..1919148 + 1263 WP_023137322.1 integrase arm-type DNA-binding domain-containing protein -
PQP80_RS09270 (1919776) 1919776..1920660 - 885 WP_023137321.1 integrase domain-containing protein -
PQP80_RS09275 (1921511) 1921511..1921843 - 333 WP_023137319.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PQP80_RS09280 (1921844) 1921844..1922101 - 258 WP_023137318.1 hypothetical protein Antitoxin
PQP80_RS09285 (1922202) 1922202..1922390 + 189 WP_223120927.1 hypothetical protein -
PQP80_RS09290 (1922449) 1922449..1922655 - 207 WP_023137317.1 helix-turn-helix transcriptional regulator -
PQP80_RS09295 (1922652) 1922652..1923131 - 480 WP_023137316.1 hypothetical protein -
PQP80_RS09300 (1923769) 1923769..1925811 - 2043 WP_274880513.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11809.59 Da        Isoelectric Point: 9.3417

>T270548 WP_023137319.1 NZ_CP117329:c1921843-1921511 [Salmonella enterica subsp. enterica serovar Muenster]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSQASFNKLTRLPVVVPVTSGGNFARAAGFTVSLDDAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9398.87 Da        Isoelectric Point: 4.4488

>AT270548 WP_023137318.1 NZ_CP117329:c1922101-1921844 [Salmonella enterica subsp. enterica serovar Muenster]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQRRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKELL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5V3ZYQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A613PBF1

References