Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 212624..213384 Replicon chromosome
Accession NZ_CP117329
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM074

Toxin (Protein)


Gene name tacT Uniprot ID A0A3V9PR68
Locus tag PQP80_RS00990 Protein ID WP_000533907.1
Coordinates 212899..213384 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PQP80_RS00985 Protein ID WP_000965886.1
Coordinates 212624..212911 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP80_RS00965 (208029) 208029..208940 + 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
PQP80_RS00970 (208950) 208950..211019 + 2070 WP_001291742.1 glycine--tRNA ligase subunit beta -
PQP80_RS00975 (211409) 211409..211837 + 429 Protein_193 IS3 family transposase -
PQP80_RS00980 (211979) 211979..212446 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
PQP80_RS00985 (212624) 212624..212911 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PQP80_RS00990 (212899) 212899..213384 + 486 WP_000533907.1 GNAT family N-acetyltransferase Toxin
PQP80_RS00995 (213755) 213755..214294 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
PQP80_RS01000 (214466) 214466..214678 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PQP80_RS01005 (214966) 214966..215256 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PQP80_RS01010 (215695) 215695..216405 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PQP80_RS01015 (216455) 216455..217429 - 975 WP_274880190.1 glyoxylate/hydroxypyruvate reductase GhrB -
PQP80_RS01020 (217648) 217648..218310 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17715.46 Da        Isoelectric Point: 9.8719

>T270545 WP_000533907.1 NZ_CP117329:212899-213384 [Salmonella enterica subsp. enterica serovar Muenster]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALIEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT270545 WP_000965886.1 NZ_CP117329:212624-212911 [Salmonella enterica subsp. enterica serovar Muenster]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PR68

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References