Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4217878..4218659 Replicon chromosome
Accession NZ_CP117327
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain RM106

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I5SY00
Locus tag PQP95_RS20370 Protein ID WP_000626104.1
Coordinates 4217878..4218369 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag PQP95_RS20375 Protein ID WP_001110452.1
Coordinates 4218366..4218659 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP95_RS20345 (4213018) 4213018..4215456 - 2439 WP_001014138.1 F4 (K88) fimbrial usher FaeD -
PQP95_RS20350 (4215466) 4215466..4216005 - 540 WP_000721295.1 type 1 fimbrial protein -
PQP95_RS20355 (4216040) 4216040..4216330 - 291 WP_274891208.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQP95_RS20360 (4216913) 4216913..4217140 + 228 WP_001519955.1 hypothetical protein -
PQP95_RS20365 (4217415) 4217415..4217663 - 249 Protein_3976 IS481 family transposase -
PQP95_RS20370 (4217878) 4217878..4218369 - 492 WP_000626104.1 GNAT family N-acetyltransferase Toxin
PQP95_RS20375 (4218366) 4218366..4218659 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
PQP95_RS20380 (4218976) 4218976..4219197 + 222 WP_021001044.1 hypothetical protein -
PQP95_RS20385 (4219463) 4219463..4220338 + 876 WP_000921676.1 AraC family transcriptional regulator -
PQP95_RS20390 (4220335) 4220335..4220622 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP95_RS20395 (4220645) 4220645..4220860 + 216 WP_001595136.1 hypothetical protein -
PQP95_RS20400 (4220868) 4220868..4221137 + 270 WP_010989096.1 hypothetical protein -
PQP95_RS20405 (4221431) 4221431..4222336 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4206242..4221137 14895


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17631.42 Da        Isoelectric Point: 7.7297

>T270537 WP_000626104.1 NZ_CP117327:c4218369-4217878 [Salmonella enterica subsp. enterica serovar Saintpaul]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT270537 WP_001110452.1 NZ_CP117327:c4218659-4218366 [Salmonella enterica subsp. enterica serovar Saintpaul]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5SY00

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References