Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4079157..4079673 Replicon chromosome
Accession NZ_CP117327
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain RM106

Toxin (Protein)


Gene name relE Uniprot ID A0A7U1KST9
Locus tag PQP95_RS19645 Protein ID WP_000220585.1
Coordinates 4079157..4079441 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U1KSR8
Locus tag PQP95_RS19650 Protein ID WP_000212721.1
Coordinates 4079431..4079673 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP95_RS19630 (4074273) 4074273..4075925 + 1653 WP_023137597.1 alpha,alpha-phosphotrehalase -
PQP95_RS19635 (4076334) 4076334..4078472 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQP95_RS19640 (4078689) 4078689..4079153 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP95_RS19645 (4079157) 4079157..4079441 - 285 WP_000220585.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP95_RS19650 (4079431) 4079431..4079673 - 243 WP_000212721.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQP95_RS19655 (4079751) 4079751..4081664 - 1914 WP_001212126.1 BglG family transcription antiterminator -
PQP95_RS19660 (4081681) 4081681..4082421 - 741 WP_000779253.1 KDGP aldolase family protein -
PQP95_RS19665 (4082418) 4082418..4083536 - 1119 WP_001139191.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP95_RS19670 (4083520) 4083520..4084653 - 1134 WP_274891193.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10878.69 Da        Isoelectric Point: 9.8739

>T270536 WP_000220585.1 NZ_CP117327:c4079441-4079157 [Salmonella enterica subsp. enterica serovar Saintpaul]
MTYELEIDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8995.36 Da        Isoelectric Point: 5.0651

>AT270536 WP_000212721.1 NZ_CP117327:c4079673-4079431 [Salmonella enterica subsp. enterica serovar Saintpaul]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTFSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U1KST9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U1KSR8

References