Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3986531..3987107 Replicon chromosome
Accession NZ_CP117327
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain RM106

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PQP95_RS19250 Protein ID WP_001131963.1
Coordinates 3986820..3987107 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag PQP95_RS19245 Protein ID WP_000063142.1
Coordinates 3986531..3986833 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP95_RS19230 (3983041) 3983041..3985191 + 2151 WP_274891180.1 pyruvate/proton symporter BtsT -
PQP95_RS19235 (3985286) 3985286..3985489 + 204 WP_000460616.1 YbdD/YjiX family protein -
PQP95_RS19240 (3985500) 3985500..3986456 + 957 WP_000187839.1 GTPase -
PQP95_RS19245 (3986531) 3986531..3986833 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
PQP95_RS19250 (3986820) 3986820..3987107 - 288 WP_001131963.1 BrnT family toxin Toxin
PQP95_RS19255 (3987376) 3987376..3988290 - 915 WP_000290512.1 restriction endonuclease -
PQP95_RS19260 (3988488) 3988488..3991997 + 3510 WP_274891181.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T270535 WP_001131963.1 NZ_CP117327:c3987107-3986820 [Salmonella enterica subsp. enterica serovar Saintpaul]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT270535 WP_000063142.1 NZ_CP117327:c3986833-3986531 [Salmonella enterica subsp. enterica serovar Saintpaul]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References