Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3381569..3382189 Replicon chromosome
Accession NZ_CP117327
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain RM106

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP95_RS16480 Protein ID WP_001280991.1
Coordinates 3381971..3382189 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP95_RS16475 Protein ID WP_000344807.1
Coordinates 3381569..3381943 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP95_RS16465 (3376708) 3376708..3377901 + 1194 WP_001039200.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP95_RS16470 (3377924) 3377924..3381073 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP95_RS16475 (3381569) 3381569..3381943 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP95_RS16480 (3381971) 3381971..3382189 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP95_RS16485 (3382368) 3382368..3382919 + 552 WP_274891120.1 maltose O-acetyltransferase -
PQP95_RS16490 (3383036) 3383036..3383506 + 471 WP_000136181.1 YlaC family protein -
PQP95_RS16495 (3383562) 3383562..3383702 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP95_RS16500 (3383708) 3383708..3383968 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP95_RS16505 (3384193) 3384193..3385743 + 1551 WP_000213139.1 EAL domain-containing protein -
PQP95_RS16515 (3385974) 3385974..3386363 + 390 WP_000961285.1 MGMT family protein -
PQP95_RS16520 (3386396) 3386396..3386965 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270532 WP_001280991.1 NZ_CP117327:3381971-3382189 [Salmonella enterica subsp. enterica serovar Saintpaul]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270532 WP_000344807.1 NZ_CP117327:3381569-3381943 [Salmonella enterica subsp. enterica serovar Saintpaul]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References