Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 5043155..5043726 Replicon chromosome
Accession NC_017573
Organism Serratia sp. AS13

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3Z6B8
Locus tag SERAS13_RS23380 Protein ID WP_013814818.1
Coordinates 5043448..5043726 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7U3Z6A2
Locus tag SERAS13_RS23375 Protein ID WP_013814817.1
Coordinates 5043155..5043424 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS13_RS23360 5039369..5040586 - 1218 WP_013814814.1 aspartate aminotransferase family protein -
SERAS13_RS23365 5040718..5041293 - 576 WP_013814815.1 aminodeoxychorismate synthase component II -
SERAS13_RS23370 5041399..5042925 - 1527 WP_013814816.1 DUF853 family protein -
SERAS13_RS23375 5043155..5043424 + 270 WP_013814817.1 hypothetical protein Antitoxin
SERAS13_RS23380 5043448..5043726 + 279 WP_013814818.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SERAS13_RS23385 5043727..5044452 - 726 WP_013814819.1 two-component system response regulator BtsR -
SERAS13_RS23390 5044452..5046137 - 1686 WP_013814820.1 sensor histidine kinase -
SERAS13_RS23395 5046297..5046866 - 570 WP_013814821.1 peptidylprolyl isomerase A -
SERAS13_RS23400 5047222..5047560 + 339 WP_041416656.1 PTS lactose/cellobiose transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10232.82 Da        Isoelectric Point: 8.5141

>T27053 WP_013814818.1 NC_017573:5043448-5043726 [Serratia sp. AS13]
VTLKWTEPAIADRMAIYDYLETKNPAAAIEIDSLISAAATRLSQNPSSGKPGRVPGTREMVIHHSYFLIYELTNGLIIML
AVVHARRQWPAN

Download         Length: 279 bp

>T27053 NC_017573:5043448-5043726 [Serratia sp. AS13]
GTGACACTCAAGTGGACGGAACCCGCGATTGCCGATCGTATGGCAATTTATGACTACCTGGAAACAAAGAATCCGGCCGC
AGCTATAGAAATTGATAGCTTGATTTCAGCAGCTGCGACACGACTCTCACAAAACCCGTCCAGTGGAAAACCAGGCCGAG
TGCCCGGTACACGTGAAATGGTTATTCATCATTCCTACTTTCTGATTTATGAATTAACCAACGGGTTAATCATTATGCTG
GCCGTAGTTCATGCCCGCCGTCAGTGGCCCGCCAATTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10394.73 Da        Isoelectric Point: 7.0169

>AT27053 WP_013814817.1 NC_017573:5043155-5043424 [Serratia sp. AS13]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVETYF
AERRSKLIR

Download         Length: 270 bp

>AT27053 NC_017573:5043155-5043424 [Serratia sp. AS13]
ATGTCTGAATCTACCGTGGTTATCCGAGTGGATGAGGAATTAAAAATCGCCTTTGCCAGCGCTGCCAAAGCAGCTGATCG
CACCGCATCTCAGTTGCTGCGCGATTTCATGCGTGATTTTGTCAGTCGGCAAACTCATCAGAAAGAGTATGAGCAGTGGC
TGCAGGAAAAAGTGGACTTAAGCCGCAAAGCGCTTAATGAAGGAAAAATCACTGATAATGAAGCAGTTGAGACCTACTTC
GCTGAACGTAGGTCAAAACTGATAAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Z6B8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U3Z6A2

References