Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 847857..848482 Replicon chromosome
Accession NZ_CP117327
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain RM106

Toxin (Protein)


Gene name vapC Uniprot ID A0A5U3PLM7
Locus tag PQP95_RS04105 Protein ID WP_023137617.1
Coordinates 848084..848482 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PQP95_RS04100 Protein ID WP_000557549.1
Coordinates 847857..848084 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP95_RS04070 (842901) 842901..844418 + 1518 WP_000003339.1 lysine--tRNA ligase -
PQP95_RS04075 (844494) 844494..845039 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PQP95_RS04080 (845304) 845304..846062 + 759 WP_000244329.1 amidase activator ActS -
PQP95_RS04090 (846347) 846347..847153 - 807 WP_010989071.1 DUF1460 domain-containing protein -
PQP95_RS04095 (847428) 847428..847680 - 253 Protein_801 hypothetical protein -
PQP95_RS04100 (847857) 847857..848084 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQP95_RS04105 (848084) 848084..848482 + 399 WP_023137617.1 tRNA(fMet)-specific endonuclease VapC Toxin
PQP95_RS04110 (849290) 849290..849826 + 537 WP_001038502.1 STM3031 family outer membrane protein -
PQP95_RS04115 (849873) 849873..850505 + 633 WP_000835265.1 YfdX family protein -
PQP95_RS04120 (851224) 851224..851808 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 846347..856268 9921


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15009.37 Da        Isoelectric Point: 7.2155

>T270525 WP_023137617.1 NZ_CP117327:848084-848482 [Salmonella enterica subsp. enterica serovar Saintpaul]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSQMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT270525 WP_000557549.1 NZ_CP117327:847857-848084 [Salmonella enterica subsp. enterica serovar Saintpaul]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5U3PLM7

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References