Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 836969..837629 Replicon chromosome
Accession NZ_CP117327
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain RM106

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQP95_RS04040 Protein ID WP_000244756.1
Coordinates 837216..837629 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQP95_RS04035 Protein ID WP_000351186.1
Coordinates 836969..837235 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP95_RS04015 (832897) 832897..834330 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PQP95_RS04020 (834489) 834489..834800 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PQP95_RS04025 (834964) 834964..835623 + 660 WP_000250289.1 hemolysin III family protein -
PQP95_RS04030 (835739) 835739..836719 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
PQP95_RS04035 (836969) 836969..837235 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQP95_RS04040 (837216) 837216..837629 + 414 WP_000244756.1 protein YgfX Toxin
PQP95_RS04045 (837682) 837682..838203 - 522 WP_001055885.1 flavodoxin FldB -
PQP95_RS04050 (838316) 838316..839212 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQP95_RS04055 (839236) 839236..839949 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQP95_RS04060 (839955) 839955..841688 + 1734 WP_023137618.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270524 WP_000244756.1 NZ_CP117327:837216-837629 [Salmonella enterica subsp. enterica serovar Saintpaul]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270524 WP_000351186.1 NZ_CP117327:836969-837235 [Salmonella enterica subsp. enterica serovar Saintpaul]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References