Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4390456..4391125 Replicon chromosome
Accession NC_017573
Organism Serratia sp. AS13

Toxin (Protein)


Gene name cptA Uniprot ID A0A7U3Z5B1
Locus tag SERAS13_RS20505 Protein ID WP_013814381.1
Coordinates 4390456..4390878 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S4YS10
Locus tag SERAS13_RS20510 Protein ID WP_004952428.1
Coordinates 4390859..4391125 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS13_RS20485 4386341..4386859 + 519 WP_004952413.1 flavodoxin FldB -
SERAS13_RS20490 4386897..4388261 - 1365 WP_013814378.1 cell envelope integrity protein CreD -
SERAS13_RS20495 4388346..4389764 - 1419 WP_013814379.1 two-component system sensor histidine kinase CreC -
SERAS13_RS20500 4389761..4390456 - 696 WP_013814380.1 two-component system response regulator CreB -
SERAS13_RS20505 4390456..4390878 - 423 WP_013814381.1 protein YgfX Toxin
SERAS13_RS20510 4390859..4391125 - 267 WP_004952428.1 FAD assembly factor SdhE Antitoxin
SERAS13_RS20515 4391450..4392442 + 993 WP_013814382.1 tRNA-modifying protein YgfZ -
SERAS13_RS20520 4392590..4393267 - 678 WP_004952439.1 hemolysin III family protein -
SERAS13_RS20525 4393458..4394066 + 609 WP_013814383.1 HD domain-containing protein -
SERAS13_RS20530 4394113..4395438 - 1326 WP_013814384.1 MHS family MFS transporter -
SERAS13_RS20535 4395435..4396088 - 654 WP_013814385.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16448.47 Da        Isoelectric Point: 10.6049

>T27052 WP_013814381.1 NC_017573:c4390878-4390456 [Serratia sp. AS13]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLVKQPWMPRYGILLTLQPIQGKKCRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Download         Length: 423 bp

>T27052 NC_017573:c4390878-4390456 [Serratia sp. AS13]
GTGGCCCAGTGGCGATGTAATGTCCGCATTTCCTGGCGCACCCAGTTACTTTCGCTGCTGACCCACGGCGTTCTTATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTACGGCCCGATCTGGCTGGTGTTGTTGACGCTGGTGGTATTTGAATGCA
TCCGCAGCCAAAAGCGCATTGCGTCACGGCAGGGCGAGCTGCGTTTGCTGGCGAATAAGCGGTTAAGTTGGCACGGACAG
GAATGGTTGCTGGTAAAGCAACCCTGGATGCCGCGTTACGGCATTTTGCTGACGCTGCAGCCGATACAGGGCAAAAAATG
CCGCCGGCTGTGGTTGGCCTCCGACAGCATGGGCAAAGCCGAATGGCGGCATCTGCGCCAGTTGTTGCTGCACCCGTCGG
CCGATGATGACGAGGAACCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10446.90 Da        Isoelectric Point: 5.0843

>AT27052 WP_004952428.1 NC_017573:c4391125-4390859 [Serratia sp. AS13]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT27052 NC_017573:c4391125-4390859 [Serratia sp. AS13]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGTGGCATGCGTGAGCTGGACATCTCAATCATGCCGTT
CTTCGAGCATGAGTACGATCAGTTGAATGACACAGACAAAGCGTTGTTTATCCGCCTGCTTGAGAGCGACGATCCCGATC
TGTTCAACTGGTTGATGAATCATGGCGCTCCGCAAGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Z5B1

Antitoxin

Source ID Structure
AlphaFold DB S4YS10

References