Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4263198..4263979 Replicon chromosome
Accession NZ_CP117326
Organism Salmonella enterica subsp. enterica serovar Newport strain RM108

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQQ05_RS20805 Protein ID WP_000625912.1
Coordinates 4263198..4263689 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQQ05_RS20810 Protein ID WP_001110450.1
Coordinates 4263686..4263979 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ05_RS20780 (4260080) 4260080..4260910 - 831 WP_001180236.1 fimbria/pilus periplasmic chaperone -
PQQ05_RS20785 (4261112) 4261112..4261417 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQQ05_RS20790 (4261948) 4261948..4262091 + 144 Protein_4064 transposase -
PQQ05_RS20795 (4262108) 4262108..4262454 + 347 Protein_4065 Rpn family recombination-promoting nuclease/putative transposase -
PQQ05_RS20800 (4262735) 4262735..4262983 - 249 Protein_4066 IS481 family transposase -
PQQ05_RS20805 (4263198) 4263198..4263689 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQQ05_RS20810 (4263686) 4263686..4263979 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQQ05_RS20815 (4264296) 4264296..4264518 + 223 Protein_4069 hypothetical protein -
PQQ05_RS20820 (4264782) 4264782..4265657 + 876 WP_000921676.1 AraC family transcriptional regulator -
PQQ05_RS20825 (4265654) 4265654..4265941 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQQ05_RS20830 (4265934) 4265934..4266116 - 183 WP_001670702.1 ATP-binding cassette domain-containing protein -
PQQ05_RS20835 (4266136) 4266136..4266235 + 100 Protein_4073 hypothetical protein -
PQQ05_RS20840 (4266233) 4266233..4266484 + 252 Protein_4074 hypothetical protein -
PQQ05_RS20845 (4266779) 4266779..4267684 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4256286..4266388 10102
- inside Genomic island - - 4252592..4266388 13796


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270518 WP_000625912.1 NZ_CP117326:c4263689-4263198 [Salmonella enterica subsp. enterica serovar Newport]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270518 WP_001110450.1 NZ_CP117326:c4263979-4263686 [Salmonella enterica subsp. enterica serovar Newport]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References