Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3421075..3421695 Replicon chromosome
Accession NZ_CP117326
Organism Salmonella enterica subsp. enterica serovar Newport strain RM108

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ05_RS16770 Protein ID WP_001280991.1
Coordinates 3421477..3421695 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ05_RS16765 Protein ID WP_000344807.1
Coordinates 3421075..3421449 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ05_RS16755 (3416214) 3416214..3417407 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ05_RS16760 (3417430) 3417430..3420579 + 3150 WP_274890115.1 efflux RND transporter permease AcrB -
PQQ05_RS16765 (3421075) 3421075..3421449 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ05_RS16770 (3421477) 3421477..3421695 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ05_RS16775 (3421874) 3421874..3422425 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQQ05_RS16780 (3422542) 3422542..3423012 + 471 WP_000136181.1 YlaC family protein -
PQQ05_RS16785 (3423068) 3423068..3423208 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ05_RS16790 (3423214) 3423214..3423474 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ05_RS16795 (3423699) 3423699..3425249 + 1551 WP_000213138.1 EAL domain-containing protein -
PQQ05_RS16805 (3425480) 3425480..3425868 + 389 Protein_3284 MGMT family protein -
PQQ05_RS16810 (3425901) 3425901..3426470 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270514 WP_001280991.1 NZ_CP117326:3421477-3421695 [Salmonella enterica subsp. enterica serovar Newport]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270514 WP_000344807.1 NZ_CP117326:3421075-3421449 [Salmonella enterica subsp. enterica serovar Newport]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References