Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 3982626..3983093 Replicon chromosome
Accession NC_017573
Organism Serratia sp. AS13

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3Z4I7
Locus tag SERAS13_RS18650 Protein ID WP_013814082.1
Coordinates 3982626..3982895 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U3Z4H1
Locus tag SERAS13_RS18655 Protein ID WP_013814083.1
Coordinates 3982899..3983093 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS13_RS18620 3977690..3978205 + 516 WP_013814078.1 hypothetical protein -
SERAS13_RS18625 3978244..3978492 + 249 WP_006316897.1 GlsB/YeaQ/YmgE family stress response membrane protein -
SERAS13_RS18630 3978542..3979822 - 1281 WP_013814079.1 uracil permease -
SERAS13_RS18635 3980015..3980641 - 627 WP_006316899.1 uracil phosphoribosyltransferase -
SERAS13_RS18640 3980897..3981934 + 1038 WP_013814080.1 phosphoribosylformylglycinamidine cyclo-ligase -
SERAS13_RS18645 3981934..3982572 + 639 WP_013814081.1 phosphoribosylglycinamide formyltransferase -
SERAS13_RS18650 3982626..3982895 - 270 WP_013814082.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SERAS13_RS18655 3982899..3983093 - 195 WP_013814083.1 hypothetical protein Antitoxin
SERAS13_RS18660 3983240..3983791 + 552 WP_004951898.1 spermidine N1-acetyltransferase -
SERAS13_RS26295 3983838..3983981 - 144 Protein_3697 IS4 family transposase -
SERAS13_RS18665 3984190..3984555 - 366 WP_013814084.1 DUF596 domain-containing protein -
SERAS13_RS26550 3984564..3985327 - 764 Protein_3699 hypothetical protein -
SERAS13_RS18675 3985689..3985943 + 255 Protein_3700 spermidine acetyltransferase -
SERAS13_RS18680 3986060..3986395 - 336 WP_013814086.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10641.22 Da        Isoelectric Point: 6.0726

>T27051 WP_013814082.1 NC_017573:c3982895-3982626 [Serratia sp. AS13]
MRIEWSREAQEELWNIIDYIDDRNPQAALILQREIETAVHSLSLNPFMYRLGRVDNTREIVVHPNYLIVYRIIGHIEVLS
VIHAKREYP

Download         Length: 270 bp

>T27051 NC_017573:c3982895-3982626 [Serratia sp. AS13]
ATGCGGATAGAATGGAGTCGTGAAGCTCAGGAAGAGCTATGGAACATTATTGATTATATTGATGATAGAAACCCGCAGGC
GGCGCTCATTTTACAGCGCGAGATCGAAACGGCGGTGCATTCGCTGTCGCTGAATCCCTTTATGTACCGGTTGGGCAGAG
TAGATAACACTCGTGAGATTGTCGTCCATCCCAACTACCTGATTGTTTATAGAATCATCGGACATATAGAAGTTCTTAGT
GTTATTCACGCTAAACGAGAATATCCCTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7443.65 Da        Isoelectric Point: 10.2045

>AT27051 WP_013814083.1 NC_017573:c3983093-3982899 [Serratia sp. AS13]
MVIKTSLSTQPTAEVAEQGESYDRWFRAKIEAAINSEKPRIPHEQVMNEMQIRLAAKKKIRKME

Download         Length: 195 bp

>AT27051 NC_017573:c3983093-3982899 [Serratia sp. AS13]
ATGGTGATCAAAACCTCCCTCTCCACCCAGCCCACAGCTGAGGTAGCCGAACAAGGCGAAAGTTACGATCGTTGGTTCCG
GGCCAAGATTGAAGCAGCCATTAACAGCGAAAAACCAAGAATTCCGCACGAGCAGGTCATGAACGAGATGCAAATTCGTT
TAGCTGCAAAGAAAAAGATACGCAAAATGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Z4I7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U3Z4H1

References