Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1001868..1002682 Replicon chromosome
Accession NZ_CP117326
Organism Salmonella enterica subsp. enterica serovar Newport strain RM108

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag PQQ05_RS04790 Protein ID WP_000971655.1
Coordinates 1001868..1002395 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag PQQ05_RS04795 Protein ID WP_000855694.1
Coordinates 1002392..1002682 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ05_RS04760 (998150) 998150..998548 + 399 Protein_932 cytoplasmic protein -
PQQ05_RS04765 (998739) 998739..998978 + 240 Protein_933 hypothetical protein -
PQQ05_RS04770 (999135) 999135..999803 + 669 WP_000445914.1 hypothetical protein -
PQQ05_RS04775 (999830) 999830..1000324 + 495 WP_000424948.1 hypothetical protein -
PQQ05_RS04780 (1000496) 1000496..1001152 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQQ05_RS04785 (1001385) 1001385..1001795 + 411 Protein_937 transposase -
PQQ05_RS04790 (1001868) 1001868..1002395 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
PQQ05_RS04795 (1002392) 1002392..1002682 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
PQQ05_RS04800 (1002952) 1002952..1003130 - 179 Protein_940 IS3 family transposase -
PQQ05_RS04805 (1003371) 1003371..1003697 + 327 WP_000393302.1 hypothetical protein -
PQQ05_RS04810 (1003970) 1003970..1004317 - 348 WP_001669174.1 DUF1493 family protein -
PQQ05_RS04815 (1004302) 1004302..1004751 - 450 WP_000381610.1 membrane protein -
PQQ05_RS04820 (1005183) 1005183..1005626 - 444 WP_000715099.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQQ05_RS04825 (1006082) 1006082..1006732 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1001571..1001795 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T270509 WP_000971655.1 NZ_CP117326:c1002395-1001868 [Salmonella enterica subsp. enterica serovar Newport]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT270509 WP_000855694.1 NZ_CP117326:c1002682-1002392 [Salmonella enterica subsp. enterica serovar Newport]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References