Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 847202..847827 Replicon chromosome
Accession NZ_CP117326
Organism Salmonella enterica subsp. enterica serovar Newport strain RM108

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PQQ05_RS04105 Protein ID WP_000911337.1
Coordinates 847429..847827 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag PQQ05_RS04100 Protein ID WP_000557545.1
Coordinates 847202..847429 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ05_RS04070 (842247) 842247..843764 + 1518 WP_000003339.1 lysine--tRNA ligase -
PQQ05_RS04075 (843840) 843840..844385 - 546 WP_000133986.1 isopentenyl-diphosphate Delta-isomerase -
PQQ05_RS04080 (844650) 844650..845408 + 759 WP_000244328.1 amidase activator ActS -
PQQ05_RS04090 (845693) 845693..846499 - 807 WP_010989071.1 DUF1460 domain-containing protein -
PQQ05_RS04095 (846774) 846774..847025 - 252 WP_001540858.1 hypothetical protein -
PQQ05_RS04100 (847202) 847202..847429 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQQ05_RS04105 (847429) 847429..847827 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
PQQ05_RS04110 (848635) 848635..849171 + 537 WP_001038502.1 STM3031 family outer membrane protein -
PQQ05_RS04115 (849218) 849218..849850 + 633 WP_000835265.1 YfdX family protein -
PQQ05_RS04120 (850569) 850569..851150 + 582 WP_001244652.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 846774..855609 8835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T270508 WP_000911337.1 NZ_CP117326:847429-847827 [Salmonella enterica subsp. enterica serovar Newport]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT270508 WP_000557545.1 NZ_CP117326:847202-847429 [Salmonella enterica subsp. enterica serovar Newport]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References