Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 836315..836975 Replicon chromosome
Accession NZ_CP117326
Organism Salmonella enterica subsp. enterica serovar Newport strain RM108

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQQ05_RS04040 Protein ID WP_000244756.1
Coordinates 836562..836975 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQQ05_RS04035 Protein ID WP_000351186.1
Coordinates 836315..836581 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ05_RS04015 (832247) 832247..833680 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PQQ05_RS04020 (833835) 833835..834149 + 315 WP_001182980.1 N(4)-acetylcytidine aminohydrolase -
PQQ05_RS04025 (834310) 834310..834969 + 660 WP_000250289.1 hemolysin III family protein -
PQQ05_RS04030 (835085) 835085..836065 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
PQQ05_RS04035 (836315) 836315..836581 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQQ05_RS04040 (836562) 836562..836975 + 414 WP_000244756.1 protein YgfX Toxin
PQQ05_RS04045 (837028) 837028..837549 - 522 WP_001055885.1 flavodoxin FldB -
PQQ05_RS04050 (837662) 837662..838558 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQQ05_RS04055 (838582) 838582..839295 + 714 WP_000745621.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQQ05_RS04060 (839301) 839301..841034 + 1734 WP_274895497.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270507 WP_000244756.1 NZ_CP117326:836562-836975 [Salmonella enterica subsp. enterica serovar Newport]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270507 WP_000351186.1 NZ_CP117326:836315-836581 [Salmonella enterica subsp. enterica serovar Newport]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References