Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4125996..4126639 Replicon chromosome
Accession NZ_CP117322
Organism Salmonella enterica subsp. enterica serovar Derby strain RM001

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag PQP82_RS19960 Protein ID WP_000048134.1
Coordinates 4126223..4126639 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag PQP82_RS19955 Protein ID WP_001261294.1
Coordinates 4125996..4126226 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP82_RS19940 (4121045) 4121045..4122697 + 1653 WP_023232256.1 alpha,alpha-phosphotrehalase -
PQP82_RS19945 (4123106) 4123106..4125244 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQP82_RS19950 (4125365) 4125365..4125829 + 465 WP_023232257.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP82_RS19955 (4125996) 4125996..4126226 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PQP82_RS19960 (4126223) 4126223..4126639 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
PQP82_RS19965 (4126700) 4126700..4128613 - 1914 WP_023232258.1 BglG family transcription antiterminator -
PQP82_RS19970 (4128630) 4128630..4129370 - 741 WP_023229489.1 KDGP aldolase family protein -
PQP82_RS19975 (4129367) 4129367..4130485 - 1119 WP_023232259.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP82_RS19980 (4130469) 4130469..4131602 - 1134 WP_023232260.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T270502 WP_000048134.1 NZ_CP117322:4126223-4126639 [Salmonella enterica subsp. enterica serovar Derby]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT270502 WP_001261294.1 NZ_CP117322:4125996-4126226 [Salmonella enterica subsp. enterica serovar Derby]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References