Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3215975..3216600 Replicon chromosome
Accession NC_017573
Organism Serratia sp. AS13

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U3Z353
Locus tag SERAS13_RS15035 Protein ID WP_013813456.1
Coordinates 3215975..3216157 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7U4DXE6
Locus tag SERAS13_RS15040 Protein ID WP_013813457.1
Coordinates 3216187..3216600 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS13_RS15030 3211837..3215808 + 3972 WP_013813455.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -
SERAS13_RS15035 3215975..3216157 + 183 WP_013813456.1 type II toxin-antitoxin system HicA family toxin Toxin
SERAS13_RS15040 3216187..3216600 + 414 WP_013813457.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SERAS13_RS15045 3216633..3217385 - 753 WP_013813458.1 L-cystine ABC transporter ATP-binding protein YecC -
SERAS13_RS15050 3217389..3218051 - 663 WP_013813459.1 cystine ABC transporter permease -
SERAS13_RS15055 3218051..3218851 - 801 WP_013813460.1 cystine ABC transporter substrate-binding protein -
SERAS13_RS15060 3218966..3219958 - 993 WP_013813461.1 D-cysteine desulfhydrase -
SERAS13_RS15065 3220084..3220593 - 510 WP_013813462.1 flagella biosynthesis regulatory protein FliZ -
SERAS13_RS15070 3220650..3221372 - 723 WP_013813463.1 RNA polymerase sigma factor FliA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6992.28 Da        Isoelectric Point: 11.3081

>T27050 WP_013813456.1 NC_017573:3215975-3216157 [Serratia sp. AS13]
VKSSELIRLLEREGWVLERIKGSHHQFKHPRSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Download         Length: 183 bp

>T27050 NC_017573:3215975-3216157 [Serratia sp. AS13]
GTGAAAAGTTCAGAACTGATCAGGCTGTTAGAACGAGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
TAAACACCCGAGATCTCGTTTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAGATCA
TGAAAGATGCCGGGCTGTGCTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15038.71 Da        Isoelectric Point: 4.6961

>AT27050 WP_013813457.1 NC_017573:3216187-3216600 [Serratia sp. AS13]
MFYPAYVHSDLDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDTLNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELSKAG

Download         Length: 414 bp

>AT27050 NC_017573:3216187-3216600 [Serratia sp. AS13]
ATGTTCTACCCTGCTTATGTACATTCAGACCTCGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGTTGTTATTT
TGCCGGCGATACCCTCGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGACGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATCCCACGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACACCCTGAACGGCGGACAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGTATCAATATCACCCTGCCGCACCGCTTGTTGAACCG
CATCGATTCACTGGTGCAGCAGCATCCTGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCCGCCGCCCGTAATGAATTAT
CGAAAGCCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Z353

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4DXE6

References