Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3393004..3393624 Replicon chromosome
Accession NZ_CP117322
Organism Salmonella enterica subsp. enterica serovar Derby strain RM001

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP82_RS16450 Protein ID WP_001280991.1
Coordinates 3393406..3393624 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4Q7HJ94
Locus tag PQP82_RS16445 Protein ID WP_023231707.1
Coordinates 3393004..3393378 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP82_RS16435 (3388143) 3388143..3389336 + 1194 WP_023231706.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP82_RS16440 (3389359) 3389359..3392508 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP82_RS16445 (3393004) 3393004..3393378 + 375 WP_023231707.1 Hha toxicity modulator TomB Antitoxin
PQP82_RS16450 (3393406) 3393406..3393624 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP82_RS16455 (3393803) 3393803..3394354 + 552 WP_001278793.1 maltose O-acetyltransferase -
PQP82_RS16460 (3394472) 3394472..3394942 + 471 WP_000136183.1 YlaC family protein -
PQP82_RS16465 (3394998) 3394998..3395138 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP82_RS16470 (3395144) 3395144..3395404 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP82_RS16475 (3395629) 3395629..3397179 + 1551 WP_023231708.1 EAL domain-containing protein -
PQP82_RS16485 (3397410) 3397410..3397799 + 390 WP_000961285.1 MGMT family protein -
PQP82_RS16490 (3397832) 3397832..3398401 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270498 WP_001280991.1 NZ_CP117322:3393406-3393624 [Salmonella enterica subsp. enterica serovar Derby]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14439.24 Da        Isoelectric Point: 5.1444

>AT270498 WP_023231707.1 NZ_CP117322:3393004-3393378 [Salmonella enterica subsp. enterica serovar Derby]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q7HJ94

References