270493

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2324901..2325423 Replicon chromosome
Accession NZ_CP117322
Organism Salmonella enterica subsp. enterica serovar Derby strain RM001

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQP82_RS11270 Protein ID WP_000221343.1
Coordinates 2324901..2325185 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP82_RS11275 Protein ID WP_000885424.1
Coordinates 2325175..2325423 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP82_RS11250 (2320976) 2320976..2322484 - 1509 WP_048348841.1 FAD-dependent oxidoreductase -
PQP82_RS11255 (2322529) 2322529..2323017 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP82_RS11260 (2323210) 2323210..2324289 + 1080 WP_023231841.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP82_RS11265 (2324341) 2324341..2324730 - 390 WP_023206403.1 RidA family protein -
PQP82_RS11270 (2324901) 2324901..2325185 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP82_RS11275 (2325175) 2325175..2325423 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP82_RS11280 (2326098) 2326098..2326520 + 423 WP_048348840.1 PTS sugar transporter subunit IIA -
PQP82_RS11285 (2326580) 2326580..2326861 + 282 WP_023218025.1 PTS sugar transporter subunit IIB -
PQP82_RS11290 (2326873) 2326873..2328264 + 1392 WP_023218026.1 PTS galactitol transporter subunit IIC -
PQP82_RS11295 (2328342) 2328342..2329853 + 1512 WP_023231843.1 FGGY family carbohydrate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2323210..2340323 17113


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T270493 WP_000221343.1 NZ_CP117322:c2325185-2324901 [Salmonella enterica subsp. enterica serovar Derby]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270493 WP_000885424.1 NZ_CP117322:c2325423-2325175 [Salmonella enterica subsp. enterica serovar Derby]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References