Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 981203..982017 | Replicon | chromosome |
Accession | NZ_CP117322 | ||
Organism | Salmonella enterica subsp. enterica serovar Derby strain RM001 |
Toxin (Protein)
Gene name | TacT3 | Uniprot ID | A0A3W0ARB0 |
Locus tag | PQP82_RS04660 | Protein ID | WP_023231965.1 |
Coordinates | 981203..981730 (-) | Length | 176 a.a. |
Antitoxin (Protein)
Gene name | TacA3 | Uniprot ID | M7S6I2 |
Locus tag | PQP82_RS04665 | Protein ID | WP_000855694.1 |
Coordinates | 981727..982017 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PQP82_RS04640 (976415) | 976415..978982 | - | 2568 | WP_001005814.1 | DNA mismatch repair protein MutS | - |
PQP82_RS04645 (979141) | 979141..979667 | + | 527 | Protein_909 | cytoplasmic protein | - |
PQP82_RS04650 (979910) | 979910..980566 | - | 657 | WP_000420451.1 | protein-serine/threonine phosphatase | - |
PQP82_RS04655 (980907) | 980907..981130 | + | 224 | Protein_911 | IS5/IS1182 family transposase | - |
PQP82_RS04660 (981203) | 981203..981730 | - | 528 | WP_023231965.1 | GNAT family N-acetyltransferase | Toxin |
PQP82_RS04665 (981727) | 981727..982017 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
PQP82_RS04670 (982287) | 982287..982476 | - | 190 | Protein_914 | IS3 family transposase | - |
PQP82_RS04675 (982881) | 982881..983324 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
PQP82_RS04680 (983781) | 983781..984431 | + | 651 | WP_001728903.1 | type III secretion system transcriptional activator InvF | - |
PQP82_RS04685 (984428) | 984428..986116 | + | 1689 | WP_000848114.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 980990..989744 | 8754 | |
- | flank | IS/Tn | - | - | 980990..981130 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19099.93 Da Isoelectric Point: 9.6420
>T270492 WP_023231965.1 NZ_CP117322:c981730-981203 [Salmonella enterica subsp. enterica serovar Derby]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYTQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYTQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT270492 WP_000855694.1 NZ_CP117322:c982017-981727 [Salmonella enterica subsp. enterica serovar Derby]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3W0ARB0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V8SJE7 |