Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 981203..982017 Replicon chromosome
Accession NZ_CP117322
Organism Salmonella enterica subsp. enterica serovar Derby strain RM001

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3W0ARB0
Locus tag PQP82_RS04660 Protein ID WP_023231965.1
Coordinates 981203..981730 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag PQP82_RS04665 Protein ID WP_000855694.1
Coordinates 981727..982017 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP82_RS04640 (976415) 976415..978982 - 2568 WP_001005814.1 DNA mismatch repair protein MutS -
PQP82_RS04645 (979141) 979141..979667 + 527 Protein_909 cytoplasmic protein -
PQP82_RS04650 (979910) 979910..980566 - 657 WP_000420451.1 protein-serine/threonine phosphatase -
PQP82_RS04655 (980907) 980907..981130 + 224 Protein_911 IS5/IS1182 family transposase -
PQP82_RS04660 (981203) 981203..981730 - 528 WP_023231965.1 GNAT family N-acetyltransferase Toxin
PQP82_RS04665 (981727) 981727..982017 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
PQP82_RS04670 (982287) 982287..982476 - 190 Protein_914 IS3 family transposase -
PQP82_RS04675 (982881) 982881..983324 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQP82_RS04680 (983781) 983781..984431 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -
PQP82_RS04685 (984428) 984428..986116 + 1689 WP_000848114.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 980990..989744 8754
- flank IS/Tn - - 980990..981130 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(1-95)


Sequences


Toxin        


Download         Length: 176 a.a.        Molecular weight: 19099.93 Da        Isoelectric Point: 9.6420

>T270492 WP_023231965.1 NZ_CP117322:c981730-981203 [Salmonella enterica subsp. enterica serovar Derby]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYTQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp


Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT270492 WP_000855694.1 NZ_CP117322:c982017-981727 [Salmonella enterica subsp. enterica serovar Derby]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3W0ARB0


Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References