Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 817015..817675 Replicon chromosome
Accession NZ_CP117322
Organism Salmonella enterica subsp. enterica serovar Derby strain RM001

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQP82_RS03915 Protein ID WP_000244756.1
Coordinates 817262..817675 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQP82_RS03910 Protein ID WP_000351186.1
Coordinates 817015..817281 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP82_RS03890 (812944) 812944..814377 - 1434 WP_023232670.1 6-phospho-beta-glucosidase BglA -
PQP82_RS03895 (814535) 814535..814846 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PQP82_RS03900 (815010) 815010..815669 + 660 WP_000250289.1 hemolysin III family protein -
PQP82_RS03905 (815785) 815785..816765 - 981 WP_023232672.1 tRNA-modifying protein YgfZ -
PQP82_RS03910 (817015) 817015..817281 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQP82_RS03915 (817262) 817262..817675 + 414 WP_000244756.1 protein YgfX Toxin
PQP82_RS03920 (817728) 817728..818249 - 522 WP_001055885.1 flavodoxin FldB -
PQP82_RS03925 (818362) 818362..819258 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQP82_RS03930 (819282) 819282..819995 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQP82_RS03935 (820001) 820001..821734 + 1734 WP_023181521.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270491 WP_000244756.1 NZ_CP117322:817262-817675 [Salmonella enterica subsp. enterica serovar Derby]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270491 WP_000351186.1 NZ_CP117322:817015-817281 [Salmonella enterica subsp. enterica serovar Derby]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References