Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1940..2499 Replicon plasmid pRM002_1
Accession NZ_CP117318
Organism Salmonella enterica subsp. enterica serovar Derby strain RM002

Toxin (Protein)


Gene name relE Uniprot ID A0A733EV64
Locus tag PQQ14_RS23475 Protein ID WP_001582571.1
Coordinates 2224..2499 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag PQQ14_RS23470 Protein ID WP_001178089.1
Coordinates 1940..2224 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ14_RS23465 (1) 1..1032 + 1032 WP_000907861.1 plasmid replication initiator RepA -
PQQ14_RS23470 (1940) 1940..2224 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
PQQ14_RS23475 (2224) 2224..2499 + 276 WP_001582571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ14_RS23480 (2605) 2605..2883 + 279 WP_001105069.1 hypothetical protein -
PQQ14_RS23485 (3078) 3078..3344 - 267 WP_000627829.1 hypothetical protein -
PQQ14_RS23490 (3344) 3344..3838 - 495 WP_001582574.1 hypothetical protein -
PQQ14_RS23495 (3894) 3894..4496 - 603 WP_000517695.1 ProQ/FINO family protein -
PQQ14_RS23500 (4850) 4850..6196 + 1347 WP_001132032.1 protein YagA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..87713 87713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10807.48 Da        Isoelectric Point: 9.5296

>T270485 WP_001582571.1 NZ_CP117318:2224-2499 [Salmonella enterica subsp. enterica serovar Derby]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNDQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT270485 WP_001178089.1 NZ_CP117318:1940-2224 [Salmonella enterica subsp. enterica serovar Derby]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A733EV64

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References