Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4257307..4258088 Replicon chromosome
Accession NZ_CP117317
Organism Salmonella enterica subsp. enterica serovar Derby strain RM002

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3Y7QYP9
Locus tag PQQ14_RS20635 Protein ID WP_023231674.1
Coordinates 4257307..4257798 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3Y7QYQ5
Locus tag PQQ14_RS20640 Protein ID WP_023231675.1
Coordinates 4257795..4258088 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ14_RS20610 (4254188) 4254188..4255018 - 831 WP_023231671.1 fimbria/pilus periplasmic chaperone -
PQQ14_RS20615 (4255220) 4255220..4255525 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQQ14_RS20620 (4256057) 4256057..4256200 + 144 Protein_4033 transposase -
PQQ14_RS20625 (4256217) 4256217..4256563 + 347 Protein_4034 Rpn family recombination-promoting nuclease/putative transposase -
PQQ14_RS20630 (4256844) 4256844..4257092 - 249 Protein_4035 IS481 family transposase -
PQQ14_RS20635 (4257307) 4257307..4257798 - 492 WP_023231674.1 GNAT family N-acetyltransferase Toxin
PQQ14_RS20640 (4257795) 4257795..4258088 - 294 WP_023231675.1 DUF1778 domain-containing protein Antitoxin
PQQ14_RS20645 (4258406) 4258406..4258628 + 223 Protein_4038 hypothetical protein -
PQQ14_RS20650 (4258894) 4258894..4259769 + 876 WP_023195838.1 AraC family transcriptional regulator -
PQQ14_RS20655 (4259766) 4259766..4260053 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQQ14_RS20660 (4260046) 4260046..4260228 - 183 WP_023231676.1 ATP-binding cassette domain-containing protein -
PQQ14_RS20665 (4260248) 4260248..4260347 + 100 Protein_4042 hypothetical protein -
PQQ14_RS20670 (4260455) 4260455..4260589 + 135 Protein_4043 hypothetical protein -
PQQ14_RS20675 (4260884) 4260884..4261789 - 906 WP_023231677.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17643.45 Da        Isoelectric Point: 7.2655

>T270482 WP_023231674.1 NZ_CP117317:c4257798-4257307 [Salmonella enterica subsp. enterica serovar Derby]
MISPPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQATGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10930.60 Da        Isoelectric Point: 9.8590

>AT270482 WP_023231675.1 NZ_CP117317:c4258088-4257795 [Salmonella enterica subsp. enterica serovar Derby]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPVPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y7QYP9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Y7QYQ5

References