270481

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4107003..4107646 Replicon chromosome
Accession NZ_CP117317
Organism Salmonella enterica subsp. enterica serovar Derby strain RM002

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag PQQ14_RS19840 Protein ID WP_000048134.1
Coordinates 4107230..4107646 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag PQQ14_RS19835 Protein ID WP_001261294.1
Coordinates 4107003..4107233 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ14_RS19820 (4102052) 4102052..4103704 + 1653 WP_023232256.1 alpha,alpha-phosphotrehalase -
PQQ14_RS19825 (4104113) 4104113..4106251 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ14_RS19830 (4106372) 4106372..4106836 + 465 WP_023232257.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ14_RS19835 (4107003) 4107003..4107233 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PQQ14_RS19840 (4107230) 4107230..4107646 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
PQQ14_RS19845 (4107707) 4107707..4109620 - 1914 WP_274881225.1 BglG family transcription antiterminator -
PQQ14_RS19850 (4109637) 4109637..4110377 - 741 WP_023229489.1 KDGP aldolase family protein -
PQQ14_RS19855 (4110374) 4110374..4111492 - 1119 WP_023232259.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ14_RS19860 (4111476) 4111476..4112609 - 1134 WP_274881227.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T270481 WP_000048134.1 NZ_CP117317:4107230-4107646 [Salmonella enterica subsp. enterica serovar Derby]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT270481 WP_001261294.1 NZ_CP117317:4107003-4107233 [Salmonella enterica subsp. enterica serovar Derby]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References