Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4064962..4065512 Replicon chromosome
Accession NZ_CP117317
Organism Salmonella enterica subsp. enterica serovar Derby strain RM002

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag PQQ14_RS19620 Protein ID WP_001199743.1
Coordinates 4064962..4065270 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag PQQ14_RS19625 Protein ID WP_000016244.1
Coordinates 4065273..4065512 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ14_RS19605 (4062986) 4062986..4063765 - 780 WP_023232244.1 HNH endonuclease -
PQQ14_RS19610 (4063926) 4063926..4064240 + 315 WP_023232245.1 hypothetical protein -
PQQ14_RS19615 (4064220) 4064220..4064527 - 308 Protein_3837 Arm DNA-binding domain-containing protein -
PQQ14_RS19620 (4064962) 4064962..4065270 - 309 WP_001199743.1 CcdB family protein Toxin
PQQ14_RS19625 (4065273) 4065273..4065512 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PQQ14_RS19630 (4065625) 4065625..4065873 - 249 WP_000168385.1 ribbon-helix-helix domain-containing protein -
PQQ14_RS19635 (4065950) 4065950..4066258 - 309 Protein_3841 DUF4942 domain-containing protein -
PQQ14_RS19640 (4066278) 4066278..4067255 - 978 WP_223156438.1 IS630 family transposase -
PQQ14_RS19650 (4068013) 4068013..4069032 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
PQQ14_RS19655 (4069060) 4069060..4069590 - 531 WP_274881221.1 gluconokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4066278..4067210 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T270480 WP_001199743.1 NZ_CP117317:c4065270-4064962 [Salmonella enterica subsp. enterica serovar Derby]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T270480 NZ_CP117317:c4065270-4064962 [Salmonella enterica subsp. enterica serovar Derby]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTAGTAAATAACCCAGTTAAGCGTCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGATGGGTTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT270480 WP_000016244.1 NZ_CP117317:c4065512-4065273 [Salmonella enterica subsp. enterica serovar Derby]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT270480 NZ_CP117317:c4065512-4065273 [Salmonella enterica subsp. enterica serovar Derby]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACGGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References