270477

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3374037..3374657 Replicon chromosome
Accession NZ_CP117317
Organism Salmonella enterica subsp. enterica serovar Derby strain RM002

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ14_RS16330 Protein ID WP_001280991.1
Coordinates 3374439..3374657 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4Q7HJ94
Locus tag PQQ14_RS16325 Protein ID WP_023231707.1
Coordinates 3374037..3374411 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ14_RS16315 (3369176) 3369176..3370369 + 1194 WP_023231706.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ14_RS16320 (3370392) 3370392..3373541 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQQ14_RS16325 (3374037) 3374037..3374411 + 375 WP_023231707.1 Hha toxicity modulator TomB Antitoxin
PQQ14_RS16330 (3374439) 3374439..3374657 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ14_RS16335 (3374836) 3374836..3375378 + 543 WP_274881080.1 maltose O-acetyltransferase -
PQQ14_RS16340 (3375505) 3375505..3375975 + 471 WP_000136183.1 YlaC family protein -
PQQ14_RS16345 (3376031) 3376031..3376171 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ14_RS16350 (3376177) 3376177..3376437 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ14_RS16355 (3376662) 3376662..3378212 + 1551 WP_023231708.1 EAL domain-containing protein -
PQQ14_RS16365 (3378443) 3378443..3378832 + 390 WP_000961285.1 MGMT family protein -
PQQ14_RS16370 (3378865) 3378865..3379434 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270477 WP_001280991.1 NZ_CP117317:3374439-3374657 [Salmonella enterica subsp. enterica serovar Derby]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14439.24 Da        Isoelectric Point: 5.1444

>AT270477 WP_023231707.1 NZ_CP117317:3374037-3374411 [Salmonella enterica subsp. enterica serovar Derby]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q7HJ94

References